High Molecular Weight Kininogen (HMWK or Fitzgerald Factor) (Last Updated - 2/27/2005)

-aka. Fitzgerald Factor
-along with prekallikrein & kaolin catalyzes the activation of Factor XII to XIIa to initiate the intrinsic pathway
-this step produces not only Factor XIIa but also kallikrein

-click here to view an image of the clotting cascade

========================================================
References:

Goodman & Gilman's: The Pharmacologic Basis Of Therapeutics - 10th Edition - 2001. Chapter 55.